C-reactive protein (CRP) is an α1-globulin predominantly synthesized by hepatocytes. It consists of five identical non-glycosylated polypeptide subunits, linked together non-covalently, forming a protein of about 115 kDa. It is composed of few or no carbohydrates. C-reactive protein is an important non-specific defence against inflammation, especially against infections. It is one of the most sensitive … Continued
C-reactive protein (CRP) is an α1-globulin predominantly synthesized by hepatocytes. It consists of five identical non-glycosylated polypeptide subunits, linked together non-covalently, forming a protein of about 115 kDa. It is composed of few or no carbohydrates. C-reactive protein is an important non-specific defence against inflammation, especially against infections. It is one of the most sensitive … Continued
Ceruloplasmin is predominantly synthesized by the cells of the liver parenchyma. This protein is an α2-globulin containing approximately 95% of the copper present in the serum. Each ceruloplasmin molecule contains between six and eight copper atoms. That is why it has long been thought that ceruloplasmin only served to transport this ion. However, it has … Continued
Complement C4 is a protein with a molecular mass of 206 kDa. The synthesis of complement C4 takes place mostly in the hepatic parenchyma, but a part is synthesised by monocytes or other tissues. Complement C4 is the enzyme of activation of complement C3 and C5. The complement C4 concentration can increase slightly following an … Continued
The plasma complement C3 is synthesised mostly by the hepatic parenchyma, but bacterial endotoxins also induce a synthesis of complement C3 by monocytes and fibroblasts. This protein interacts in complex ways with antibody-antigen complexes, with one and the other in an independent manner, but with cell membranes also, so as to help the destruction of … Continued
Beta2-microglobin (ß2M) is a low molecular weight (11.8 kD) protein present on the surface of many cells. Beta2-microglobin exists in two forms: in free form or membrane form, identified as the light chain of the class I major histocompatibility complex (MHC). Despite its small size, allowing it to pass through the glomerular membrane, less than … Continued
In 1928, Todd demonstrated the production by group A streptococci of a lysine from human red blood cells. He demonstrated its antigenic character, which causes the production of circulating antistreptolysin O (ASO) antibodies after infection by the microorganism. Streptolysin O is a soluble protein of 69 kDa that binds to the erythrocyte membrane and permeabilises … Continued
Lipids are transported in serum in the form of micelles, known as lipoproteins. Lipoproteins are complex macromolecules made up of protein, cholesterol and phospholipids as external structure and esters of cholesterol and triglycerides as internal structure. Lipoproteins are classified according to their increasing density: chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins … Continued
Lipids are transported in serum in the form of micelles, known as lipoproteins. Lipoproteins are complex macromolecules made up of protein, cholesterol and phospholipids as external structure and esters of cholesterol and triglycerides as internal structure. Lipoproteins are classified according to their increasing density: chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins … Continued
Antithrombin III (AT III) is a regulatory glycoprotein in hemostasis and thrombosis. It is the functional heparin cofactor necessary for its anticoagulant action. It is involved in the control of the coagulation cascade. Levels increase in the presence of an acute inflammatory phase (hepatitis, inflammation, vitamin K deficiency, etc.). AT III deficiency may predispose to … Continued
