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Alpha2-macroglobulin

The alpha2-macroglobulin is a very large size protease inhibitor (725 kDa), primarily synthesized by cells of the hepatic parenchyma. It is involved in the inhibition of enzymes involved in the kinin-kallikrein, complement, coagulation and even fibrinolytic systems. In addition to these inhibitor roles, the alpha2-macroglobulin is used as a carrier for many small peptides (such as cytokines or growth factors), and also with divalent cations (particularly zinc). 

The serum concentration of alpha2-macroglobulin varies with the age and gender of the individual. 

An increase in serum alpha2-macroglobulin can occur following the nephrotic syndrome. High levels are also associated with estrogen stimulation, as in pregnancy or with oral contraceptive use.

A decrease in the alpha2-macroglobulin concentration can occur due to the inflammatory phase in the case of pancreatitis, and can even indicate the presence of prostate carcinoma. The alpha2-macroglobulin level can also be lower in some individuals due to genetic variation.

 

 

Low Control

Quality controls for Serum/Plasma and Urine are available. More details are available in their respective Instruction For Use:

 

  • For Serum/plasma

MPCOSFTEN-17H29.pdf

  • For Urine

MGCU1FTEN-17I05.pdf

Medium Control

Quality controls for Serum/Plasma and Urine are available. More details are available in their respective Instruction For Use:

 

  • For Serum/plasma

MPCONFTEN-17H30.pdf

  • For Urine

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High Control

Quality controls for Serum/Plasma and Urine are available. More details are available in their respective Instruction For Use:

 

  • For Serum/plasma

MPCOXFTEN-17H31.pdf

  • For Urine

MGCU2FTEN-17I06.pdf